Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain

•Sigma-1 antagonism enhances immune-driven opioid analgesia during inflammation.•Inhibition of sigma-1 receptors decreases neuroinflammation in the DRG.•Sigma-1 receptor antagonism inhibits neuroinflammation in the brain and spinal cord.•Sigma-1 antagonists may constitute a new class of analgesics.