MicroRNA-638 induces apoptosis and autophagy in human liver cancer cells by targeting enhancer of zeste homolog 2 (EZH2)

Hongyu Zhang,Hongxia Liang,Shuhuan Wu,Yingying Zhang,Zujiang Yu

Environmental Toxicology and Pharmacology（2021）

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摘要

•MicroRNA-638 is downregulated in liver cancer tissues and cell lines.•Overexpression of miR-638 inhibits liver cancer cell proliferation.•Overexpression of miR-638 induces apoptosis and autophagy in liver cancer cells.•MicroRNA-638 exerts its effects by targeting enhancer of zeste homolog 2(EZH2).

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关键词

MicroRNA,Liver cancer,Apoptosis,Autophagy,Anti-proliferative,Western blotting

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