Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease
JHEP Reports(2021)
摘要
•Obesity induces TSP1 expression in several tissues, such as adipose tissue and liver.•Macrophages are an important cellular source of increased TSP1 in mouse NASH livers.•Deletion of TSP1 in macrophages protects mice from diet-induced NASH.•SMPDL3B negatively regulates TSP1-mediated macrophage activation.
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关键词
TSP1,Obesity,NAFLD,NASH,SMPDL3B,Macrophage
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