Costameric Integrin and Sarcoglycan Protein Levels Are Altered in a Drosophila Model for Limb-girdle Muscular Dystrophy Type 2H.

Simranjot Bawa,Samantha Gameros, Kenny Baumann,David S. Brooks,Joseph A. Kollhoff,Michal Zolkiewski,Andrea David Re Cecconi,Nicolo Panini,Massimo Russo,Rosanna Piccirillo,David K. Johnson,Maithri M. Kashipathy,Kevin P. Battaile,Scott Lovell,Samuel E. A. Bouyain,Jessica Kawakami,Erika R. Geisbrecht

Molecular biology of the cell（2021）

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摘要

Expression of human disease-causing LGMD2H alleles in Drosophila causes muscle degeneration and elevated levels of integrin and sarcoglycan costamere proteins, likely exacerbating disease progression.

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