Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Caitlin N. Spaulding,Roger D. Klein,Ségolène Ruer,Andrew L. Kau,Henry L. Schreiber,Zachary T. Cusumano,Karen W. Dodson,Jerome S. Pinkner,Daved H. Fremont,James W. Janetka,Han Remaut,Jeffrey I. Gordon,Scott J. Hultgren

NATURE（2017）

引用 202|浏览5

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摘要

Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.

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关键词

Bacterial genes,Microbiome,Pathogens,Target identification,Science,Humanities and Social Sciences,multidisciplinary

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