Recombinant Paraprobiotics As a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans.

Hanchen Li,Ambily Abraham,David Gazzola,Yan Hu,Gillian Beamer,Kelly Flanagan,Ernesto Soto,Florentina Rus,Zeynep Mirza,Austin Draper,Sridhar Vakalapudi, Cheryl Stockman,Perry Bain,Joseph F. Urban,Gary R. Ostroff,Raffi Aroian

Antimicrobial Agents and Chemotherapy（2020）

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摘要

Gastrointestinal nematodes (GINs) of humans, e.g., hookworms, negatively impact childhood growth, cognition, nutrition, educational attainment, income, productivity, and pregnancy. Hundreds of millions of people are targeted with mass drug administration (MDA) of donated benzimidazole anthelmintics.

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Bacillus thuringiensis,anthelmintic,crystal protein,gastrointestinal nematodes,helminths,hookworms,paraprobiotic,soil-transmitted helminths

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