Aucubin alleviates diabetic nephropathy by inhibiting NF-κB activation and inducing SIRT1/SIRT3-FOXO3a signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

The potential protective mechanism of Aucubin (AU) in STZ/HFD-induced diabetic nephropathy (DN). AU decreased inflammatory cytokines production by down-regulated NF-κB activation. Besides, AU ameliorates oxidative stress in kidneys of HFD/STZ-induced diabetic mice, and these effects are found at least in part through modulation of the Nrf2 and FOXO3a pathways via up-regulated SIRT1 and SIRT3 activation.