Grindstone Chemistry: Design, One-Pot Synthesis, And Promising Anticancer Activity Of Spiro[Acridine-9,2 '-Indoline]-1,3,8-Trione Derivatives Against The Mcf-7 Cancer Cell Line
MOLECULES(2020)
摘要
In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1H-spiro [acridine-9,2 '-indoline]-1,3,8-trione derivatives was achieved via a four-component cyclocondensation reaction, which was carried out in solvent-free conditions, and using p-toluenesulfonic acid (p-TSA) as a catalyst. The product was confirmed by FT-IR, H-1-NMR, C-13-NMR, mass spectra, and elemental analysis. Furthermore, the anticancer activity was screened for all compounds. Among these compounds, compound 1c was more effective (GI(50) 0.01 mu m) against MCF-7 cancer cell lines than standard and other compounds. Therefore, the objective of this study was achieved with a few promising molecules having been demonstrated to be potential anticancer agents.
更多查看译文
关键词
isatin, indole, solvent-free conditions, cyclocondensation, grinding, p-TSA catalyst, anticancer activity
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络