(S)-1-(5-(4-Methylpiperazin-1-yl)-2,4-dinitrophenyl)pyrrolidine-2-carboxylic acid as a derivatization reagent for ultrasensitive detection of amine enantiomers by HPLC-MS/MS and its application to the chiral metabolite analysis of (R)-1-aminoindan in saliva
Journal of Pharmaceutical and Biomedical Analysis（2021）
摘要
•A novel chiral derivatization reagent was synthesized.•Analysis of chiral amines was performed by LC–MS/MS.•Efficient enantioseparation and sensitive detection of chiral amines were performed.•R-AI in saliva was successfully determined.
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关键词
Chiral amines,Chiral derivatization reagent,Mass spectrometry,Saliva analysis
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