Assessment of Serum Malondialdehyde (MDA) and Urinary 8-hydroxydeoxyguanosine (8-OHdG) in Egyptian Children with Type I Diabetes Mellitus and Factors affecting

Hyperglycemia generates oxidative stress. Malondialdehyde (MDA) is one of the indicators of oxidative stress. 8-hydroxydeoxyguanosine (8-OHdG) is a sensitive, stable, and integral marker of oxidative damage. This study estimated serum MDA level and urinary 8hydroxydeoxyguanosine (8-OHdG) in type 1 DM Egyptian children and to correlate their values with severity of type 1 DM. Material and Methods : Our study included 132 children with type 1 DM and 50 children ages matched healthy. Clinical examination and evaluation of lipid profile, glycosylated hemoglobin, serum malondialdehyde (MDA) and urinary 8-hydroxydeoxyguanosine were done for all subjects. Results : MDA and 8-OHdG were significantly higher in diabetic children than control. MDA was significantly positively correlated with urinary level of 8-OHdG in diabetic children. 8-OHdG showed a negative correlation with age. Conclusion, the gained results support that oxidative stress in Type 1 diabetic may start early in disease course. Therefore, MDA and urinary 8-OHdG can be a beneficial marker of oxidative stress assessment and glycemic control should be intensified to prevent diabetic complications. Using antioxidant medication could help in delaying diabetic complications.