Abnormal social behavior and altered gene expression in mice lacking NDRG2

Mika Takarada-Iemata,Toru Yoshihara,Nahoko Okitani,Keiko Iwata,Tsuyoshi Hattori,Hiroshi Ishii,Jureepon Roboon,Dinh Thi Nguyen,Qiyan Fan,Takashi Tamatani,Takumi Nishiuchi,Masahide Asano,Osamu Hori

Neuroscience Letters（2021）

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摘要

•NDRG2 expression increased during postnatal brain development.•NDRG2 deficiency altered gene expression in the brain, including Bmp4 and Per2.•NDRG2 knockout mice showed abnormal social behavior.

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关键词

ADHD,ASD,BMP4,CNS,GFAP,MBP,NDRG2,PER2

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