Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways.

Milton Guilherme Forestieri Fernandes,Julia Xiao Xuan Luo,Qiao-Ling Cui,Kelly Perlman,Florian Pernin,Moein Yaqubi,Jeffery A Hall,Roy Dudley,Myriam Srour,Charles P Couturier,Kevin Petrecca,Catherine Larochelle,Luke M Healy,Jo Anne Stratton,Timothy E Kennedy,Jack P Antel

Communications biology（2021）

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摘要

Myelin destruction and oligodendrocyte (OL) death consequent to metabolic stress is a feature of CNS disorders across the age spectrum. Using cells derived from surgically resected tissue, we demonstrate that young (更多

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