Why tube fimbria-end is the favorite site of carcinogenesis in hereditary ovarian cancer? A review of literature and our institution experience

Background: Ovarian cancer (OC) is the first cause of death among gynecological malignancies. BRCA mutated women are at risk to develop an OC between 35-60% for BRCA1 and 10-27% in BRCA2 by the age of 70 years. Salpingo-oophorectomy seems to be the only technique that can reduce the risk of OC in this population. Materials and Methods: The authors reviewed PubMed literature about the role of STIC in fimbrial carcinogenesis and describe their 11 cases treated with a total salpingo-oophorectomy (removal of the fallopian tube comprising also the cornual site). Results: No case of STIC or invasive cancer were found in the cornual site of fallopian tube but only one case of STIC was found in the fimbrial end, as literature shows. Conclusion: In this review of the literature, the authors wanted to better understand how carcinogenesis works in the salpinges and if minimal prophylactic surgery can be a safe option.