Testing Considerations For Phosphatidylinositol-3-Kinase Catalytic Subunit Alpha As An Emerging Biomarker In Advanced Breast Cancer
CANCER MEDICINE(2020)
摘要
Breast cancer is the most common cancer in women, and approximately 71% of carcinomas are hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-not-amplified (HER2-negative). Pathogenesis of breast cancer is associated with dysregulation of several signaling pathways, including the phosphatidylinositol-3-kinase (PI3K) pathway.PIK3CA, the gene encoding PI3K catalytic subunit p110 alpha, is mutated in 20%-40% of breast cancer patients. Several PI3K inhibitors have been developed and one, alpelisib, was recently approved for use inPIK3CA-mutated, HR+, HER2-negative advanced breast cancer. There are numerous types of assays and methods used in clinical studies to determinePIK3CAstatus in cancers. Additionally, there are several factors to consider forPIK3CAtesting in clinical practice, including choice of assay, source of sample, and test timing. In this review, we discuss the use ofPIK3CAas a biomarker to guide treatment decisions in patients with HR+, HER2-negative advanced breast cancer, as well as practical considerations and recommendations for testing.
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关键词
advanced breast cancer, alpelisib, biomarker, companion diagnostic, PIK3CA
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