Oncologic Outcomes Of Alcohol Induced Hcc After Liver Transplantation

Aims: Alcohol is a well-known oncogenic substance that many people still have abused. Alcohol can make liver not only cirrhosis but also hepatocellular carcinoma (HCC). More and more patients who have HCC undergo liver transplantation (LT) these days. However, there was no report to research the oncologic outcomes of LT for those patients. Methods: The data from 470 patients with HCC who underwent LT were retrospectively collected and analyzed. We compared oncologic outcomes between alcoholic and non-alcoholic HCC patients. Results: Out of 470 HCC patients, 20 patients had alcoholic HCC before LT. There were no differences in Milan criteria proportion and AFP level between the groups. The mean MELD score of the groups was not different. Living donor LTs were performed in 70% of non-alcoholic group and 80% of alcoholic group, which was no significantly different. RBC transfusion and operation time were not different during the operations. However, recurrence-free survival rates of alcoholic HCC group was worse than non-alcoholic group (3yr RFS; 58.9% vs 85.7% respectively, P=0.032). Conclusions: Alcohol induced HCC patients showed worse recurrence-free survival after LT than non-alcoholic HCC patients. Further study will be needed to clarify the cause of these results.