The Effectiveness Of Perampanel For Myoclonic Seizures In Down Syndrome With Isodicentric Chromosome 21
CASE REPORTS IN NEUROLOGY(2020)
摘要
Epileptic seizures are common in the elderly Down syndrome population. We encountered a patient with Down syndrome in whom karyotyping showed the rare isodicentric chromosome 21 and who suffered from myoclonic seizures. A 52-year-old woman with Down syndrome experienced sudden onset of drowsiness and frequent myoclonic jerks in the upper body. Video-EEG recordings demonstrated generalized polyspike-wave discharges consistent with myoclonic jerks, which were exacerbated by photo-stimulation. Her myoclonus completely resolved with perampanel administration. Perampanel was effective for myoclonic seizures in our patient. We suggest that perampanel is an option as first-line therapy for epilepsy and myoclonus in elderly Down syndrome patients.
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关键词
Down syndrome, Epilepsy, Isodicentric chromosome 21, Myoclonus, Perampanel
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