TWO Yb(III)-CONTAINING COORDINATION POLYMERS: STRUCTURAL INSIGHTS AND SYNERGY EFFECT WITH SEVENTY-FLAVOR PEARL PILLS ON CEREBRAL ISCHEMIA BY REGULATING MONOAMINE NEUROTRANSMITTERS

In this work, we report the synthesis of two new Yb(III)-based coordination polymers [Yb(Btca)(Idc)(H 2 O)] n ( 1 , HBtca = 1H-benzo[d][1,2,3]triazole-5-carboxylic acid and H 3 Idc = 1H-imidazole-4,5-dicarboxylic acid) and [Yb 2 (Thz) 3· 8H 2 O)]·H 2 O ( 2 , H 2 Thz = thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid) prepared under the solvothermal conditions using two heterodonor organic ligands. The two complexes are fully determined via single crystal X-ray diffraction along with the elemental analysis. Furthermore, the synergy effect of compounds 1 and 2 with seventy-flavor pearl pills on the cerebral ischemic events is evaluated in vivo. Firstly, the enzyme-linked immunosorbent assay (ELISA) is performed to measure the content of dopamine and 5-serotonin in the brain after treatment with compounds 1 and 2 . Then, the reactive oxygen species (ROS) detection is conducted to determine the inhibitory effect of the compounds on the inflammatory level in the brain.