CORRELATION OF INFLAMMATORY MARKERS AND CARDIAC ABNORMALITIES WITH SPIROMETRIC SEVERITY OF COPD

SESSION TITLE: Obstructive Lung Disease Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: • To study the ECG and Echocardiographic (ECHO) abnormalities in patients of COPD, and its correlation with spirometric severity • To study the levels of systemic inflammatory markers –C-Reactive protein (CRP) and Mean Platelet Volume (MPV) and its correlation with spirometric severity.• To study the correlation between inflammatory markers (CRP & MPV) and cardiac abnormalities (ECG& ECHO). METHODS: Cross sectional analytical study was conducted in the department of Respiratory Medicine,Chettinad Hospital & Research Institute,Chennai-India.The study was approved by Institutional Human Ethical Committee and conducted after obtaining informed consent. 55 stable COPD (both Inpatients & outpatients) were recruited in this study.The selected patients were subjected to Spirometry, ECG, Electrocardiography, CRP, and MPV.Data was analysed using SPSS version 17.0 and correlation of variables was done using Pearson chi-square test with p-value <0.05 as significant. RESULTS: A total of 55 stable COPD subjects, with the mean age of 56.5 years and male preponderance of 63.6% were observed. According to GOLD severity 30.9 % & 50.9 % had moderate and severe COPD respectively.58.1% were smokers among which 43.6% of smokers with pack years of >20 had moderate to severe COPD.The most common ECG pattern in Moderate and Severe COPD was p pulmonale (45.4%) followed by Right Axis Deviation (41.8%). Echocardiographic findings of Pulmonary hypertension, Right atrium and ventricle dilatation and Tricuspid regurgitation correlated significantly with severity of COPD.There was a significant increase in Mean CRP and MPV values with the severity of COPD. Subjects with cardiac abnormality had a mean MPV of >9.1 with 96.7% sensitivity and 84% of specificity.CRP levels of >6.3 were significantly observed with cardiac abnormality with 96.7% sensitivity and 84.0% specificity. CONCLUSIONS: There was a significant association of cardiac abnormalities and inflammatory markers with severity of COPD. Hence, early cardiac assessment and evaluation of inflammatory markers would enable us to predict the severity of COPD, to optimize management in order to prevent morbidity and mortality. CLINICAL IMPLICATIONS: Cardiac abnormalities in COPD have a significant correlation with inflammatory markers and severity of COPD. Hence the use of inflammatory markers would help to predict the presence of cardiac comorbidity to enable optimal treatment strategies in management of COPD DISCLOSURES: No relevant relationships by Meenakshi Narasimhan, source=Web Response No relevant relationships by Suresh SAGADEVAN, source=Web Response No relevant relationships by Aruna Shanmuganathan, source=Web Response No relevant relationships by ROSHINIDEVI SURESH, source=Web Response