Polyvinylpyrrolidone- graft -poly(2-hydroxyethylmethacrylate) hydrogel membranes for encapsulated forms of drugs

Synthesis of the polyvinylpyrrolidone- graft -poly(2-hydroxyethylmethacrylate) hydrogel membranes while varying ratio between components, monomer concentration, chemical nature of the initiators and solvents, as well as temperature was investigated in details. Based on this study, optimal conditions of the polymerization formation of hydrogel membranes were established. The structural parameters of the hydrogel networks and their permeability for water and low molecular weight soluble substances were investigated. The main factors of effects on the structure of film hydrogels and their operational properties are established. The technological scheme of the formation of hydrogel membrane coatings for the fabrication of encapsulated forms of prolonged release of drugs is developed. Graphical abstract