Autophagy Inhibition Enhances Cdk4/6 Inhibitor-Induced Apoptosis In T(8;21) Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is a genetically and clinically heterogeneous disease. Although t(8;21) AML patients have a more favorable prognosis than other cytogenetic subgroups, nearly 40% of t(8;21) AML patients experience relapse. Therefore, novel therapeutic approaches based on a better understanding of the biology of t(8;21) AML need to be developed.