Abstract PO-013: Defining immune infiltrate heterogeneity and its role in ovarian cancer chemotherapy resistance using single cell RNA sequencing

Objectives: Immune cell infiltration is correlated with therapy response in ovarian cancer (OC), but exceptions to this correlation are numerous, which could be due to heterogeneity in the immune cell composition and functional phenotype of immune cells. To better understand the immune landscape of OC and to develop biomarkers predictive of OC response to chemotherapy we initiated a prospective study to analyze the unique molecular and histopathological characteristics of tumor samples taken during primary debulking, interval debulking and at recurrence. Methods: We have enrolled over 100 women and have completed single cell RNA sequencing (scRNAseq), multiplex immunohistochemical assays, HE 2020 Sep 17-18. Philadelphia (PA): AACR; Cancer Res 2020;80(21 Suppl):Abstract nr PO-013.