Effect Of High-Intensity Exercise On Respiratory And Peripheral Muscle Oxygenation In Hf And Copd-Hf Patients

Purpose: To investigate the impact of high-intensity exercise on respiratory (Res) and peripheral muscle oxygenation (Pm) in coexistent chronic obstructive pulmonary disease (COPD)-heart failure (HF) and HF patients. Methods: Eleven COPD-HF and eleven HF patients were underwent evaluation by a lung function test and echocardiography. Another two different days: 1) patients performed cardiopulmonary exercise testing (CPX) and the constant load exercise (CE) (80% of peak work rate of CPX), was performed on a cycle ergometer until the limit of tolerance (Tlim). Relative blood concentrations of oxyhemoglobin ([O2Hb]), deoxyhemoglobin ([HHb]) of Res (intercostal muscles) and VLm (right vastus lateralis) were measured using near infrared spectroscopy. Results: Res, VLm [O2Hb], VLm ([HHb]) and Tlim presented increases in HF in contrast to COPD-HF patients (p Conclusion: COPD when associated to HF produce negative impact on blood flow of ventilatory muscles and exercise intolerance. Support: FAPESP: 2018/18133-0, 2015/26501-1, 2018/03233-0, CNPQ.