Enantioselective Halocyclization Of Indole Derivatives: Using 1,3-Dihalohydantoins With Anionic Chiral Co(Iii) Complexes
SYNLETT(2021)
摘要
Highly enantioselective halocyclization reactions of indole derivatives, including tryptophols and tryptamines, have been accomplished by means of anionic chiral Co(III) complexes and 1,3-dihalohydantoins (as little as 0.50 equiv). 3-Halo-fused indolines were obtained in excellent yields (up to 98%) and enantioselectivities (up to 98% ee), employing the chiral anion phase-transfer-catalysis strategy.
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关键词
anion phase-transfer catalysis, chiral Co(III) complex, Bronsted acid, indole derivatives, halocyclization
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