Involvement of Sarco/endoplasmic Reticulum Ca2+-ATPase (SERCA) in Mprα (Paqr7)-Mediated Progesterone Induction of Vascular Smooth Muscle Relaxation.
Endocrinology and metabolism/American journal of physiology endocrinology and metabolism(2021)
摘要
The rapid effects of progesterone on cytosolic Ca2+ levels and relaxation of VSMCs through mPRα involve regulation of the functions of SERCA2 and PLB through Gi, MAP kinase, and Akt signaling pathways and downregulation of RhoA activity.
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关键词
calcium,mPR alpha,muscle relaxation,SERCA,vascular smooth muscle cells
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