Synergistic Antibacterial And Anti-Inflammatory Effects Of A Drug-Loaded Self-Standing Porphyrin-Cof Membrane For Efficient Skin Wound Healing
ADVANCED HEALTHCARE MATERIALS(2021)
摘要
Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large-area, homogeneous, and self-standing porphyrin-covalent organic framework (COF)-based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph-membrane exhibits highly effective antibacterial and anti-inflammatory effects via synergistic light-induced singlet oxygen (O-1(2)) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph-membrane-based biocompatible "band-aid" type dressing is fabricated, and its excellent anti-infection and tissue remodeling activities are fully evidenced by in vivo chronic wound-healing experiments. This study may inspire and promote the fabrication of many more new types of COF-based multifunctional biomaterials for various skin injuries in clinical medicine.
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关键词
COF band-aids, drug delivery, multifunctional porphyrin-COF membranes, photodynamic therapy, wound healing
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