Docking Simulation and Anti-Inflammatory Profile of Some Synthesized Heterodimer of Pyrazole
Russian Journal of Bioorganic Chemistry(2020)
摘要
In the present studies, novel pyrazole derivatives have been synthesized linked through various linkers for the anti-inflammatory evaluation. The anti-inflammatory evaluation have been carried out by molecular docking and in vivo experimental models. The docking studies of these synthesized compounds have been performed with the active site of COX-2 compared to celecoxib and in vivo on carrageenan induced rat paw edema. Among all compounds ( VIa and VIb ) shown good anti-inflammatory activity.
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关键词
pyrazole,inflammation,anti-inflammatory,drug design,molecular modeling
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