C-terminal lysine clipping of IgG1: impact on binding to human FcγRIIIa and neonatal Fc receptors

Valegh Faid,Yann Leblanc,Marie Berger,Alexander Seifert,Nicolas Bihoreau,Guillaume Chevreux

European Journal of Pharmaceutical Sciences（2021）

引用 9|浏览3

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摘要

•Investigation of the impact of IgG1 C-terminal lysine clipping on Fc receptors binding•Three charge variants (K0, K1, K2) obtained at high purity by SCX chromatography•In-depth biophysical characterization of the purified samples demonstrated high level of structural homogeneity apart from C-terminal lysine contents•No impact of C-terminal lysine clipping on binding to human FcRn/FcγIIIa receptors

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关键词

C-terminal lysine clipping,charge variants,FcγRIIIa,FcRn,affinity chromatography,surface plasmon resonance,mass spectrometry,monoclonal antibody

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