Efficient Treatment of Experimental Cerebral Malaria by an Artemisone-SMEDDS System: Impact of Application Route and Dosing Frequency

Johanna Zech,Nadeen Salaymeh,Nicholas H. Hunt,Karsten Maeder,Jacob Golenser

Antimicrobial agents and chemotherapy（2021）

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摘要

Artemisone (ART) has been successfully tested in vitro and in animal models against several diseases. However, its poor aqueous solubility and limited chemical stability are serious challenges.

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artemisone,malaria,SMEDDS,microemulsion,drug delivery,self-emulsifying,oral,nasal,intraperitoneal

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