Combination ceftaroline and daptomycin salvage therapy for complicated methicillin-resistant Staphylococcus aureus bacteraemia compared with standard of care

•Methicillin-resistant Staphylococcus aureus bacteraemia has high mortality.•Vancomycin may be suboptimal for difficult-to-clear bloodstream infections.•Daptomycin and ceftaroline combination reduced the incidence of clinical failure.•Daptomycin and ceftaroline may decrease the time to blood culture clearance.