The pathological significance of LOXL2 in pre-metastatic niche formation of HCC and its related molecular mechanism

Sifan Wu,Xiaoxia Xing,Yaohui Wang,Xi Zhang,Miao Li,Mimi Wang,Zhiming Wang,Jie Chen,Dongmei Gao,Yan Zhao,Rongxin Chen,Zhenggang Ren,Kezhi Zhang,Jiefeng Cui

European Journal of Cancer（2021）

引用 21|浏览15

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摘要

•LOXL2 promotes lung pre-metastatic niche formation and lung metastasis occurrence.•LOXL2-caused matrix stiffening also contributes to pre-metastatic niche formation.•Targeting LOXL2-induced pre-metastatic niche may be an intervention approach.

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关键词

Hepatocellular carcinoma,Pre-metastatic niche,LOXL2

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