Adenomyoepithelioma With Myoepithelial Carcinoma Of The Breast With Axillary Lymph Node Metastasis: Two Case Reports And Review Of The Literature

Objectives: Adenomyoepithelioma (AME) of the breast exhibits characteristic proliferation of the epithelial and myoepithelial cells. Most AMEs are benign, but the 2 inherent cell types can become malignant. The present study reports 2 cases of AME with myoepithelial carcinoma of the breast, one with axillary lymph node metastasis.Methods: A modified radical mastectomy was performed in a 67-year-old woman, because a sentinel lymph node biopsy revealed one metastatic lymph node composed of a myoepithelial carcinoma component. Despite receiving radiotherapy and chemotherapy, the patient died from lung and brain metastases 21 months later. In the second case, breast-conserving surgery with sentinel lymph node biopsy was performed in a 55-year-old woman. Following additional treatment with radiotherapy and chemotherapy, there were no signs of recurrence or metastasis.Results: The tumors of the 2 patients were diagnosed as malignant, based on their high mitotic rate and severe nuclear atypia.Conclusions: Based on previously reported cases with distant metastases, the prognosis of myoepithelial carcinoma is poor. Myoepithelial carcinoma should be followed up with careful screening and treated aggressively.