c-Myb interferes with inflammatory IL1α-NF-κB pathway in breast cancer cells

Monik Dúckaa,Martina Kučeríková,Filip Trčka,Jakub Červinka,Elisabetta Biglieri,Jan Šmarda,Lubor Borsig,Petr Beneš,Lucia Knopfová

Neoplasia（2021）

引用 11|浏览10

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摘要

•c-Myb attenuates NF-κB activity in breast cancer.•Interaction with co-activator p300 is required for NF-κB suppression by c-Myb.•c-Myb negatively regulates IL1a transcription in several ER- breast cancer cell lines.•Inhibition of IL1α expression mediates the anti-inflammatory effect of c-Myb.

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关键词

Breast cancer,c-Myb,IL1α,NF-κB,Inflammation,Transactivation

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