Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma.

Tiffany S Y Chan,Daniel Picard,Cynthia E Hawkins,Mei Lu,Stefan Pfister,Andrey Korshunov,Martine F Roussel, Robert J Wechsler-Reya,Jack Henkin,Eric Bouffet,Annie Huang

Neuro-oncology advances（2021）

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摘要

Our data underscore the importance of TSP-1 as a critical tumor suppressor in MB and highlight TSP-1 peptidomimetics as promising novel therapeutics for the most lethal subtype of MB.

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关键词

AKT,MYC,PI3K,TSP-1,medulloblastoma

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