Developing embolic material and preparation method thereof

The invention discloses a developing embolic material and a preparation method of the developing embolic material. Developable barium-alginate embolic microspheres encapsulating in-situ synthesis barium sulfate particles are prepared from one step by the adoption of an electrostatic spraying technology, integration of a developing agent and the embolic material is achieved, and the problems that when interventional therapy is clinically adopted, indirect developing exists and rechecking is difficult are solved. The mono-dispersion microspheres with the grain diameter being 100-1000 microns can be obtained by adjusting and controlling the electrostatic spraying parameter, so that the mono-dispersion microspheres with the grain diameter being 100-1000 microns are suitable for embolism of vessels of different calibers. The development agent, barium sulfate, and the barium-alginate microspheres are formed at the same time, and the barium sulfate particles are evenly distributed in the microspheres and firmly fixed. Extracorporeal simulation experiments prove that the developing microspheres are quite stable within the testing time of 50 days. A big-eared rabbit right kidney arterial embolism experiment proves that the developing microspheres have a good developing effect and an embolic effect. Because the electrostatic spraying technology has the characteristics of being simple, rapid and low in cost, the one-step preparation method has the production potential.