The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders

Gerwyn Morris,Basant K. Puri,Chiara C. Bortolasci,Andre Carvalho,Michael Berk,Ken Walder,Estefania G. Moreira,Michael Maes

Neuroscience & Biobehavioral Reviews（2021）

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摘要

•HDL, ApoA1 and PON1 are related to inflammation and lipid peroxidation in psychiatry.•Reduced HDL contributes both localised and systemic inflammation.•Homocysteine contributes to inflammation, oxidative stress and mitochondrial dysfunction.

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关键词

Depression,Bipolar disorder,Schizophrenia,Inflammation,Oxidative stress,Neuroimmunomodulation,Psychiatry,Mental disorders,Aetiology,Pathophysiology

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