SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

Narayanappa Amruta,Wesley H. Chastain, Meshi Paz,Rebecca J. Solch, Isabel C. Murray-Brown,Jaime B. Befeler,Timothy E. Gressett,Michele T. Longo,Elizabeth B. Engler-Chiurazzi,Gregory Bix

Cytokine & Growth Factor Reviews（2021）

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摘要

•SARS-CoV-2, a novel coronavirus that severely affects the respiratory system, is the cause of the COVID-19 pandemic.•Illustrates immune cell infiltration, cytokine storm, and inflammation.•Discusses SARS-CoV-2 mediates neuroinflammation and the impact of COVID-19 in neurological disorders.•ATN-161 inhibits SARS-CoV-2 spike protein binding to both integrin α5β1 and α5β1/hACE2.•Summarizes available treatments and vaccines to treat COVID-19 patients.

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关键词

ACE,BBB,CNS,COVID-19,CSF,GBS,GM,IFNs,IL,MERS-CoV,NK,ORFs,PD,RGD,SARS-CoV-2,TNF

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