Role of Phosphorylation and Hyperphosphorylation of Tau in Its Interaction with βα Dimeric Tubulin Studied from a Bioinformatics Perspective.

Hrushikesh Dixit,Selvaa Kumar C, Ruchi Chaudhary, Divya Thaker,Nikhil Gadewal,Debjani Dasgupta

Avicenna journal of medical biotechnology（2021）

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摘要

This study being the first of its kind emphasizes the role of projection domain and proline rich region of β-subunit in stabilizing the tau-tubulin interaction and also the effect of hyperphosphorylation in protein-protein and protein-drug binding.

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Phosphorylation,Tau proteins,Tubulin,Vinblastine

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