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Screening of lipid metabolism biomarkers in patients with coronary heart disease via ultra-performance liquid chromatography–high resolution mass spectrometry

Fang Cai,Fandong Ren,Yunmei Zhang,Xiaoxue Ding,Guanghui Fu,Dabing Ren,Lijuan Yang,Ning Chen,Ying Shang,Yongdan Hu,Lunzhao Yi,Hong Zhang

Journal of Chromatography B（2021）

Cited 7|Views11
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Abstract
•An effective pre-processing method evaluation criterion was established.•m/z segmented scanning was used to improve the quality of MS/MS.•316 lipid metabolites were annotated by three-level qualitative strategy.•Integrated qualitative filtering strategy was used to filter target mass spectra.•Potential lipid markers were screened in patients with CHD by PLS-DA and VIP method.
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Key words
Lipid metabolites,Coronary heart disease,Integrated filtering strategy,Mass spectrometry,Biomarkers
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