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吗啡镇痛对晚期肝癌患者血清TNF-α及IL-6水平影响的分析

Qian HUANG,Ming ZHANG,He-dai LIU,Hong-xiang LIANG,Cui-tang YUAN,Ju-di XU,Zhi-yong YANG

Labeled Immunoassays and Clinical Medicine（2019）

Cited 4|Views18
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Abstract
目的 考察吗啡镇痛对晚期肝癌患者血清TNF-α及IL-6水平影响.方法 将120例晚期肝癌患者随机分为曲马多缓释片组和吗啡组,每组60例.曲马多缓释片组给予曲马多缓释片片口服治疗,吗啡组给予口服硫酸吗啡缓释片治疗.比较两组患者镇痛效果、不良反应和血清TNF-α及IL-6水平.结果 吗啡组镇痛效果显著优于曲马多缓释片组(P＜0.05).吗啡组患者不良反应发生率显著高于曲马多缓释片组(P＜0.05).吗啡组患者镇痛后1周和1个月时血清TNF-α及IL-6水平显著低于曲马多缓释片组(P＜0.05).结论 吗啡镇痛可有效降低晚期肝癌患者血清TNF-α及IL-6水平.
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