A novel diagnostic marker for progressive supranuclear palsy targeting atrophy of the subthalamic nucleus

Shinsuke Fujioka,Takashi Morishita,Koichi Takano,Nobutaka Takahashi,Kanako Kurihara,Akihiro Nishida,Takayasu Mishima,Midori Suenaga,Yoichi Matsunaga,Yoshi Tsuboi

Journal of the Neurological Sciences（2021）

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摘要

•The subthalamic nucleus was assessed by conventional MRI.•Anatomical 3D image construction and volumetric analyses were performed.•The four major neurodegenerative parkinsonian disorders were evaluated.•The volume of the nucleus was the smallest in progressive supranuclear palsy.•Atrophy of the nucleus is a useful biomarker for progressive supranuclear palsy.

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关键词

Subthalamic nucleus,Magnetic resonance imaging,Atrophy,Progressive supranuclear palsy,Neurodegenerative disorders

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