Maternal overnutrition before and during pregnancy induces DNA damage in male offspring: A rabbit model

Ana María Salazar,Monserrat Sordo, Erika Navarrete-Monroy,Pablo Pánico,Andrea Díaz-Villaseñor,Rodrigo Montúfar-Chaveznava,Ivette Caldelas,Patricia Ostrosky-Wegman

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2021）

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摘要

•Maternal over-nutrition during pregnancy induces sex-dependent effects in the adult offspring.•Adult male offspring showed a significant increase in micronucleus frequency.•Adult female offspring showed increased oxidative stress in the liver.•In utero exposures may influence the risk of non-communicable diseases in adulthood.

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SD,HFCD,MN-RET,MetS,GLU,CHOL,LDL,HDL,TBARS,MDA,FFA

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