Grasping and Manipulation: Neural Bases and Anatomical Circuitry in Humans

•Grasping actions require the integration of visual information and motor signals.•Grasping activates both dorso-dorsal and dorso-ventral parieto-frontal circuits.•Manipulative actions are based on somatomotor transformations.•Manipulation relies on partially segregated functional circuits with respect to grasping.•Both grasping and manipulation involve basal ganglia and cerebellum.