Circulating Prostaglandin E2: a Novel Potential Prognostic Biomarker in Patients with Hepatocellular Carcinoma

Pelizzaro Filippo, Kitenge Maria Piera,Cardin Romilda,Ponzoni Alberto,Cillo Umberto,Vitale Alessandro,Businello Gianluca,Munari Giada,Fassan Matteo,Farinati Fabio

Clinical and Experimental Medicine（2021）

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摘要

Introduction: Hepatocellular carcinoma (HCC) develops almost invariably on a chronic liver disease characterized by persistent inflammation and several evidences suggest that prostaglandins are involved in tumor growth. Monoacylglycerol lipase (MAGL), Cyclooxygenase-2 (COX-2) and Prostaglandin E2 (PGE2) proved to promote tumor growth, inhibit apoptosis and enhance cell proliferation and invasion.

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关键词

Hepatocellular carcinoma,Prostaglandin E2,Monoacylglycerol lipase,Cyclooxygenase-2,Survival

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