Abstract PS4-43: Prediction of breast ductal carcinoma in situ recurrence using histomics analysis of stromal features from hematoxylin and eosin stain-based images

OBJECTIVE It remains a challenge to predict individual risk for recurrence after primary treatment of ductal carcinoma in situ (DCIS). While DCIS is contained within the duct, prior studies have pointed to the importance of stromal collagen in cancer progression. Using hematoxylin and eosin (HE inverse variance (AUC: 0.64, p-value: 0.046) feature based on grey-level cooccurrences matrix (GLCM) and complexity (AUC 0.65, p-value: 0.025) feature based on neighborhood grey tone difference matrix (NGTDM). CONCLUSION Textural stromal features extracted from HE 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS4-43.