Palladium-Catalyzed Regioselective C-H Functionalization/Annulation Reaction Of Amides And Allylbenzenes For The Synthesis Of Isoquinolinones And Pyridinones

A regioselective C-H functionalization/annulation reaction of N-sulfonyl amides and allylbenzenes through a palladium-catalyzed C(sp(2))-H allylation/aminopalladation/beta-H elimination/isomerization sequence has been reported. Various aryl and alkenyl carboxamides are found to be efficient substrates to construct isoquinolinones and pyridinones in up to 96% yield. Using ambient air as the terminal oxidant is another advantage regarding environmental friendliness and operational simplicity.