Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation

Jin Zhang,Changsong Wang,Hongliang Wang,Xueting Li,Jingjing Xu,Kaijiang Yu

International Immunopharmacology（2021）

引用 26|浏览6

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摘要

•Loganin alleviates inflammatory response in sepsis-induced ALI mice.•Loganin inhibits M1 macrophage polarization and induces M2 polarization.•Loganin impedes inflammasome-mediated caspase-1 activation and IL-1β secretion.•Loganin exerts anti-inflammatory effect by blocking the ERK and NF-κB pathway.

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关键词

Loganin,Acute lung injury,Anti-inflammation,Macrophage polarization,NLRP3 inflammasome

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