Gain Of 'Faonction', Loss Of Fibrosis
TRENDS IN ENDOCRINOLOGY AND METABOLISM(2021)
摘要
Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular respiration, mitochondrial dynamics, and tubular epithelial cell (TEC) differentiation, while upregulation of FAO in kidney tubules provided protection from kidney fibrosis and functional decline.
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关键词
chronic kidney disease,fatty acid oxidation,kidney fibrosis,tubular epithelial cell
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