Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats

Chen Xing, Yanzhao Zhou,Huan Xu,Mengnan Ding,Yifan Zhang,Min Zhang,Meiru Hu,Xin Huang,Lun Song

Neuroscience Research（2021）

引用 11|浏览2

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摘要

•Sleep deprivation (SD) for 3 days induces anxiety and depressive-like behaviors in rats.•SD alters the circadian oscillations of clock genes in the hypothalamus.•SD alters the expression of BBB tight junction protein and disrupts BBB integrity.•Neuroinflammation is involved in SD-induced changes in neuropathology and behaviors.

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关键词

AQP-4,BBB,Bmal1,Cry1,Cry2,Clock,Dbp,GFAP,Iba-1,IL-1β,IL-6,TNF-α,Per1/Per2,Rev-erbα,RORα,TJ,SCN,SD

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