Mesalazine Suppresses Proinflammatory Cytokines in Patients with Acute Anterior Uveitis Independently of HLA-B27.

Nikola Smatlik,Nourhan Mortada,Martin Röcken,Amir S Yazdi,Manfred Zierhut

Ocular immunology and inflammation（2022）

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摘要

Here we show that mesalazine (5-ASA) inhibits the transcription of proinflammatory and (ER) stress associated cytokines and markers, independently of the HLA-B27 status. Results show the similarities of both AAU types but do not decipher the mechanism why the HLA-B27 status determines the therapeutic response to mesalazine in AAU.

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关键词

ER stress,HLA-B27,Uveitis,cytokines,inflammation,mesalazine

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