A new porous Co(II)‐coordination polymer for the chemical fixation of CO2 and treatment effect against tuberculosis by reducing the pckA expression in Mycobacterium tuberculosis

Using the mixed-ligand method, a novel coordination polymer containing Co(II) of [Co(ditb)(tdc)](n)center dot 5nH(2)O (1) was prepared by reacting rigid 2,5-thiophenedicarboxylic acid with flexible 1,4-di(1H-1,2,4-triazol-1-yl)butane using the slow evaporation method. Active samples of1(1afor short) showed good stability and the ability to capture CO2. It can be used as a potential heterogeneous catalyst for chemical immobilization of epoxide and CO(2)to form cyclic carbonates. In addition, catalyst1aretained its original structure after four times of reuse. Its biological properties were assessed againstMycobacterium tuberculosis(M.TB) bothin vivoandin vitro.First, the bactericidal ability of the compound againstM.TBwas measured by a sterilization curve. Then, the expression ofpckAgene related toM.TBsurvival was detected using reverse transcription-polymerase chain reaction. For thein vivostudy, the colony-forming unit determination was performed for evaluating the anti-bacterial effect of the compound, and the enzyme-linked immunosorbent assay was used for the inflammatory cytokine measurementin vivo.Through molecular docking simulations, all three types of polar atoms on the complex were confirmed to have chances of interacting with the protein.